Time-Resolved Circular Dichroism: What Can We Learn on Conformational Changes?
Time-resolved circular dichroism (CD) measurements can yield relevant information on the dynamics of conformational changes in molecules on the condition that some a priori knowledge is obtained. This can be the use of simple models such as the excitonic coupling or the octant rule or the phenomenological relationship between far-UV CD and secondary structures in proteins for example. This article describes such experiments where CD has brought relevant conformational information.
Keywords: Circular dichroism, conformational dynamics, proteins, protein folding