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Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation
Yongbo Liu, Xiaohua Gao, Dorrah Deeb, Ali S. Arbab, Scott A. Dulchavsky and Subhash C. Gautam

anthohumol (XN), a prenylated chalcone present in hops exhibits anti-inflammatory, antioxidant and anticancer activity. In the present study we show that XN inhibits the proliferation of mouse lymphoma cells and IL-2 induced proliferation and cell cycle progression in mouse splenic T cells. The suppression of T cell proliferation by XN was due to the inhibition of IL-2 induced Janus kinase/signal transducers and activators of transcription (Jak/STAT) and extracellular signal-regulated kinase 1 and 2 (Erk1/2) signaling pathways. XN also inhibited proliferation-related cellular proteins such as c-Myc, c-Fos and NF-κB and cyclin D1. Thus, understanding of IL-2 induced cell signaling pathways in normal T cells, which are constitutively turned on in T cell lymphomas may facilitate development of XN for the treatment of hematologic cancers.

Keywords: Xanthohumol, IL-2, Jak/STAT, Erk1/2, proliferation

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