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Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study
Mahesh R. Khairnar, Umesh Wadgave, Harish Jadhav and Rahul Naik

Introduction: Oral cancer is considered to be a global pandemic. The study was conducted to assess the anticancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines.

Material and methods: Anticancer activity of CHX and Cranberry extract (CE) was assessed against AW13516 (poorly to moderately differentiated squamous cell carcinoma of tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assay at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) Mumbai, India. Three dose-related parameters GI50, TGI and LC50 were calculated for each drug.

Results: CE (80μg/ml) showed no anti-cancer property against AW13516 cell line; however it showed 70.6% growth inhibition against KB cell line. CHX demonstrated 80.15% & 95.7% of growth inhibition against AW13516 & KB cell line respectively. Both the drugs were less potential than positive control drug Adriamycin, as reflected by their GI50, TGI and LC50 values.

Conclusion: CHX exhibited better anti-cancer properties than CE for both the oral cancer cell lines.

Keywords: anticancer activity, chlorhexidine, cranberry, oral cancer.

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