Indirect cell death and the LQ model in SBRT and SRS
Chang W. Song, Stephanie Terezakis, Bahman Emami, Robert J Griffin, Paul W Sperduto, Mi-Sook Kim and L Chinsoo Cho
High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.
Keywords: LQ model, SBRT, SRS, indirect cell death, secondary cell death