Adjuvant treatment of unresectable choroid plexus carcinoma with literature review
Seema Gupta, Nuzhat Husain, Sham Sundar, A. Shah, and Chitiz Srivastava
Choroid plexus carcinomas are rare and arise from the choroid plexus, with invariably poor prognosis. We report an unusual case of an 8-year old male who presented with symptoms of increased intracranial pressure with radiological evidence of brain intraventricular lesion which was proved to be choroid plexus carcinoma on histopathology and immunohistochemistry. Treatment consisted of limited surgery followed by craniospinal irradiation and boost to the local tumor.
Post treatment there was evidence of residual disease with no significant clinical improvement for which patient was managed conservatively with steroids along with chemotherapy with poor outcome.
Hence aggressive surgical resection of the tumor is the most relevant prognostic predictor for survival, and is associated with poor prognosis if not completely excised irrespective of adjuvant treatment.
Keywords: Choroid plexus carcinoma, immunohistochemistry, prognosis, chemotherapy, radiotherapy
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