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Bioelectronic Interface between Biomolecular Logic Systems and Microelectronics
Maria Gamella, Inhee Lee, Nataliia Guz, David Blaauw and Evgeny Katz

A biomolecular computing system based on enzyme-catalyzed reactions was interfaced with modified electrodes releasing enzymes catalytically digesting starch and producing glucose. The produced glucose was used to activate a millimeter-size biofuel cell connected to a microelectronic chip. Overall, the complex biocatalytic cascade logically processing biomolecular input signals resulted in production of electrical power sufficient for activating the microelectronic chips, thus representing for the first time a biomolecular-microelectronic system processing chemical signals and managing power produced. Both sides of the multi-component system, biomolecular signal processing and micro-power managing parts, can be extended to longer biocatalytic logic cascades and microelectronic circuits, respectively. The first presented example of the bioelectronic system is considered as a background for future bio-robotic machines with integrated logic and power components.

Keywords: Electronic chip, enzyme logic, logic gate, biofuel cell, alginate, biomolecular release

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