The role of oxidative stress markers in development of endometrial polyp
Mehmet Çınar, Özlem Gün Eryılmaz, Şule Özel, Rahime Bedir Fındık, Hatice Kansu and Gülnur Özakşit
Objective: To evaluate the association of the oxidative stress markers in patients with endometrial polyp.
Methods: A total of forty nine patients between 28-47 years of ages who have a suspect evidence of endometrial polyp on transvaginal sonography were enrolled for the study. Hysterosonography was applied all of the patients and patients then were divided into two groups in terms of their hysteroscopic findings. Group 1(control group, n=27) defined who has no endometrial pathology and group 2 (study group, n=22) defined has one or more endometrial polyp on hysteroscopy with guided biopsy. The diagnosis was established by histopathological examination polyps. The parameters compared between groups were; age, body mass index, catalase (CAT), xsantine oxidase (XO), malondialdehyde (MDA) levels.
Results: There were no statistically significant differences between groups in terms of age and BMI. Catalase, xsantine oxidase and malondialdehyde levels were statically significantly different between the groups (p < 0,05). The mean of polyp diameter size were 17.95 ±0.45 mm and the number of the polyp per patient was 1.54 ± 0.67.
Conclusion: According to our study, serum catalase, xsantine oxidase and malondialdehyde levels may be discriminative parameters for patients with endometrial polyp.
Keywords: Endometrial polyp, oxidative stress, Catalase, Xsantine oxidase, Malondialdehyde, inflammation