Could there be any role of thiol disulphide homeostasis and ischemia modified albumin in the pathogenesis of endometrial polyps?
Gulnur Ozaksit, Aytekin Tokmak, Arzu Kosem, Meryem Kuru-Pekcan and Ozcan Erel
Objective: We searched thiol/disulphide homeostasis ischemia modified albumin (IMA) in patients with and without endometrial polyp (EP) to evaluate whether there is an association between serum oxidative stress and EPs.
Methods: A total of 87 women were enrolled into this study. All patients were evaluated with office hysteroscopy, and then those with EPs underwent operative hysteroscopy. 43 of these women had pathologically confirmed EPs (study group) and 44 had not (control group). Fasting blood samples were obtained from the antecubital vein before the procedure in all women. Thiol/disulphide levels were analyzed with a newly developed method by Erel et al. IMA measurement was performed using an indirect method based on the colorimetric assay as previously defined.
Results: There were no significant differences between the 2 groups in terms of demographic characteristics including age, body mass index, and past obstetric history. Similarly no significant difference was observed regarding infertility ratio and smoking status. Native thiol, total thiol, and disulphide levels were found to be 263.6±63.3 μmol/l vs. 280.9±63.8 μmol/l (p:0.208), 296.9±64.9 μmol/l vs. 315.2±67.3 μmol/l (p:0.202), and 16.6±6.5 μmol/l vs.17.1±7.8 μmol/l ( p:0.759) in the study and control groups, respectively. There was also no significant difference with regard to serum IMA level (46.5±12.1 vs. 44.9±12.6; p: 0.539).
Conclusion: Serum thiol/disulphide homeostasis and IMA levels have no significant effect in the pathogenesis of EPs.
Keywords: Endometrial polyp, thiol disulphide homeostasis, ischemia modified albumin, oxidative stress marker