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Gamma knife radiosurgery for brain metastases from small-cell lung cancer: Institutional experience over more than a decade and review of the literature
Diogo Cordeiro, Zhiyuan Xu, Matthew Shepard, Darrah Sheehan, Chelsea Li and Jason Sheehan

Introduction: In the present study, we reviewed the efficacy of stereotactic radiosurgery (SRS) alone or in combination with WBRT, for the treatment of patients with BM secondary to SCLC. We further identified patient and treatment specific factors that correlated with improved survival.

Methods: Forty-one patients treated with GKRS for BM secondary to SCLC from 2004 to 2017 at the University of Virginia were identified with histopathologically proven SCLC and included in the study.

Results: Following the first GKRS treatment, the median survival was 6 months (1-41 months). There was no statistical difference in overall survival and tumor control between the patients who had PCI, WBRT or upfront GKRS. The only factor associated with decreased OS after the diagnosis of BM from SCLC was active extracranial disease (P=0.045, HR=2.354).

Conclusion: Stereotactic radiosurgery is a reasonable treatment option for patients with brain metastases of SCLC who had PCI or WBRT failure.

Keywords: Brain metastases, Gamma Knife radiosurgery, small-cell lung cancer, stereotactic radiosurgery, SCLC, SRS.

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