Stereotactic radiosurgery for primary tumors of the spine and spinal cord
Erinma Elibe, David Boyce-Fappiano, Samuel Ryu, M. Salim Siddiqui, Ian Lee, Jack Rock and Farzan Siddiqui
Purpose: The purpose of this study was to evaluate the role of stereotactic radiosurgery in the treatment of primary tumors of the spine and spinal cord.
Methods: An Institutional Review Board approved retrospective analysis of 30 patients with primary spine tumors treated at a single institution was performed. Post-treatment pain, neurological, and radiographic responses were the endpoints.
Results: Nine patients were treated for benign tumors, and 21 patients were treated for malignant tumors. The median dose delivered was 16 Gy in one fraction. Median follow up was 13.13 months (range, 1 month-84 months). Pain relief was 88% initially. Pain recurred in five patients with a median time to recurrence of 5 months (range, 3.6 months – 80 months). Neurological improvement was achieved in 65% of patients. Three patients experienced a recurrence in their neurological deficit (at 3.6 months, 1.6 years, and 3.7 years after SRS). Radiographic control was achieved in 77% of sites treated with SRS. Thirteen of the treated sites recurred with a median time of 9.9 months. Two long-term toxicities were observed (asymptomatic radio-necrosis of the erector spinae muscle and foot drop).
Conclusions: Our results suggest that SRS is a safe and effective treatment option for primary tumors of the spine and spinal cord.
Keywords: primary spine tumor, stereotactic radiosurgery, stereotactic body radiation therapy