Photo-thermal Ablation of Cancer by Using Photosensitive Nanoparticles
Toshiyuke Watanabe, Mari Tsubouchi, Kenro Totani, Kenji Kamada, Youichiro Iwase, Kouichi Kondao and Kazunori Kataoka
Two-photon initiated thermal ablation of cancer was investigated. Polymer nanoparticles consisting of two-photon chromophore were synthesized by using poly(ethylene glycol)-poly(b-benzyl-L-aspartate) block co-polymer. Mono dispersed nanoparticles having 70 nm diameters were obtained. In the case of MPPBT nanoparticle, quantum yield decreases and two-photon absorption cross section increases compared with that of MPPBT solution which is preferable for photo thermal ablation of cancer. Uptake of nanoparticles into Hela cell was confirmed by fluorescent imaging. FDA assay reveals that two-photon thermal ablation by using nanoparticles is effective for cancer therapy.