A Dibromobenzene Derivative for Photodynamic Therapy
Thibault Gallavardin, Mathieu Maurin, Patrick L. Baldeck, Olivier Stéphan, Mikael Lindgren, Frédéric Lerouge, Stéphane Parola, Olivier Maury and Chantal Andraud
Synthesis and photophysical properties of a quadrupolar hydrophobic photosensitizer are described. This photosensitizer presents significant two-photon absorption and leads to singlet oxygen generation for type II phototherapy with a high quantum yield. A preliminary cell death experiment upon one-photon resonant irradiation has been carried out using this photosensitizer.
Keywords: singlet oxygen generation, two-photon absorption, photodynamic therapy.